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Product name

Rottlerin, Kinase inhibitor

Description

Kinase inhibitor

Biological description

Originally reported to inhibit PKC isoforms, especially PKCδ and CAM-KIII. Also inhibits MAPKAP-K2 and PRAK (IC₅₀ values are 5.4 and 1.9 μM, respectively), CHK2, PLK1, PIM3 and SRPK1.

Purity

> 95%

Chemical name

3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone

Molecular weight

516.55

Chemical structure

Molecular formula

C₃₀H₂₈O₈

CAS Number

82-08-6

PubChem identifier

5281847

Storage instructions

Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Solubility overview

Soluble in DMSO to 100 mM

Handling

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

SMILES

CC(=O)c4c(O)c(Cc2c(O)c(c1OC(C)(C)C=Cc1c2O)C(=O)/C=C/c3ccccc3)c(O)c(C)c4O

Source

Synthetic